Introduction : Pertussis (whooping cough) pose a public health challenge, particularly in infants, who are at high risk for severe disease and complications. Early diagnosis in neonates is often difficult due to atypical clinical presentation. A 15-day-old male child presented with symptoms consistent with pertussis, including cough, breath-holding spells, and cyanosis. Diagnosis was confirmed by PCR test, which was positive for the IS481 and ptxS1 genes of Pertussis. The child showed clinical improvement after azithromycin treatment, and chemoprophylaxis was given to close contacts. Public health interventions like active case search, vaccination drives, and health education, were implemented to control pertussis transmission. No additional cases were identified during the active case search. This report emphasizes the need for healthcare providers to consider pertussis as a differential diagnosis in neonates with cough and breathing difficulties, and highlights the effectiveness of prompt treatment and public health interventions in controlling pertussis transmission.